Mutt and Jeff was also the first comic strip to tackle political topics when the pint-sized Jeff ran for president in 1908, and Mutt and Jeff was also the first comic strip to be adapted into a cartoon series (hundreds of Mutt and Jeff cartoons were made during the silent era). Mutt and Jeff also launched an enormous amount of merchandise and was one of the first comic strips to appear in comic books (it was on the cover of Famous Funnies #1 in 1933). The extent of its influence on American culture can be indicated by the fact that people still refer to the pairing of a tall man and a short guy as 'Mutt and Jeff.'
Comic strip expert Jeffrey Lindenblatt is editing
With the recent announcement by Fantagraphics of the reprinting of Walt Kelly's Pogo, Drawn & Quarterly's Gasoline Alley/Walt & Skeezix volumes, and IDW's Dick Tracy series it appears that this is quickly becoming a new golden age of comic strip reprints (see 'Comic Strip Collections Highlighted in New York Times').