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In the game, players take the role of rival biker gangs, out to control territory to reap the monetary rewards of controlling contraband. With each turn, new tiles are laid, which represent new territory, and clubs attempt to control that space by placing members of their gang (represented by tokens of Members on bikes, and Prospects who are on foot) in that space. However, other players can challenge for right to territory, which will lead to conflict. The game is about making and breaking alliances, much like GF9’s Spartacus. The gang with the most money at the end of six turns wins.
The game is for 3 – 4 players, and plays in about an hour. MSRP is $49.99.
The name Men of Mayhem is a direct reference from the show to a patch club members are given who have shed blood in the interest of the club. For SOA members, it is also a reference to "Mister Mayhem," aka Death.