Satoshi Kon's Tokyo Godfathers opened slightly stronger than his Millenium Actress, averaging $3,750 per screen in a very limited release.  The film has done far better with critics than it has with audiences at least at this point.  The Rotten Tomatoes Website gives Kon's latest anime feature a very strong 86% positive rating with 19 positive reviews and only 3 negative notices.  Many critics noted Kon's highly individualistic approach, which owes almost nothing to the conventions of anime -- 'Here's an anime film for viewers who don't like anime,' etc.  Loosely based on John Ford's Three Godfathers, Tokyo Godfathers is, at its core, a very sentimental film that flies in the face of modern conventions and twenty-first century cynicism. 

While it is too early to tell if the film will be able to generate much box office momentum, it should do well on DVD as Kon's reputation grows.  Although he has only directed three films (Perfect Blue, Millenium Actress, and Tokyo Godfathers, all features), Kon has already demonstrated complete mastery of the medium -- you would have to go back to Orson Welles to find a filmmaker so on top of his game from the very beginning.