This game is about families attempting to fight the Plague that has infected their town. Players must help save the other townsfolk while they try to prosper in their new countryside residence. Messina 1847 is co-designed by Vladimir Suchy, who was also responsible for Underwater Cities and Praga (see "'Praga Caput Regni'").

The game is for one to four players, and has a playing time of 60-120 minutes. Thus far, the MSRP for this game has not been revealed.