DC Comics (with six) and Fantagraphics (with 5) dominated the 2005 Harvey Awards held at the MoCCA Festival in New York where a number of books including DC's The New Frontier, Fantagraphics The Complete Peanuts and Eightball, Dark Horse Comics' The Escapist, and Jeff Smith's Bone all ended up with multiple awards.  Andy Runton, creator of Owly (Top Shelf) was named Best New Talent and Michael Chabon Presents: The Amazing Adventures of the Escapist (Dark Horse) was named Best New Series (as well as Best Anthology).

Other key awards included Best Writer, given to Daniel Clowes for Eightball (Fantagrahics); Best Artist, which went to Darwyn Cooke for The New Frontier; and Best Cartoonist, which went to Jeff Smith for Bone (which also won Best Graphic Album of Previously Published Work).  James Jean won Best Cover Artist for his work on DC/Vertigo's Fables, and Dan Clowes' Eightball #23 won the award for Best Single Issue or Story.  The New Frontier was judged Best Continuing/Limited Series, and Fantagraphics' The Complete Peanuts 1950-52 won Best Domestic Reprint Project as well as a Special Award for Excellence in Presentation.

Other awards of note included Best Graphic Album of Original Work given to Blacksad 2, published by ibooks; and Best Edition of Foreign Material, which went to Vertical Inc. for their edition of Osamu Tezuka's Buddha.  Top Shelf's Comic Book Artist won Best Biographical, Historical or Journalistic Presentation, while Kyle Baker's work on Plastic Man won a Special Award for Humor in Comics and Patrick McDonald's Mutts was judged the Best Syndicated Strip or Panel.