The issue marks the end of the “Go Down Swining” arc, which pits Peter Parker against Red Goblin, none other than Peter’s long-time enemy Norman Osborn and the Carnage symbiote.
Amazing Spider-Man #800 marks Slott’s penultimate issue on a ten-year run with the web slinger, which he finishes with #801 before he makes the move to Iron Man (see “Dan Slott Leaving Spider-Man”).