This booster set continues the story from their first release Jaelara. A civil war has begun, and an exiled bloodline from the slums of Anahata emerges: a bloodline of vampires! Origins showcases 12 new champions and 145 timeline cards. It also debuts the green faction of Phage, which focuses on survival, replication, and decay, and it adds new key mechanics such as Stack Modifiers, Warp, and Fatigue. The set rarities break down to include 73 commons, 40 uncommons, 32 rares, and 12 Starter cards.

Foils cards are included in 1 of 17 packs, and Epic Rares appear in 1 of 7 packs. Display boxes come with a box topper pack that has two foil champions and 1 of 5 different foil Epic Rares.