This is the first Issue of a new story arc revolving around Marvel's First Family, the Fantastic Four. The new arc adds new Fantastic Four heroes to the mix as well as new boss battles with the likes of Kang and Doctor Doom. It includes 15 new Main Characters and 26 new Supporting Characters, and the box comes with 55 playable cards and a rulesheet.

Upper Deck recently announced major licenses for its Vs and Legendary franchises at Gen Con (see "Major Licenses for 'Vs.' and 'Legendary'").