This game is part of the Nuclear War family of games, the first of which was designed by Doug Malewicki and self-published in 1965. Flying Buffalo picked up the rights in 1983 and published three installments of the game, starting the Nuclear Escalation. They continued to publish the game until the owner, Rick Loomis, passed away in 2019 (see "R.I.P. Rick Loomis"). The rights to this game then headed to Webbed Sphere, Inc. (see "Acquires Flying Buffalo, Inc."), and eventually into the hands of Mr. B Games when Webbed Sphere acquired them as well (see "Acquires Mr. B Games").  

Nuclear Destruction is a standalone game. Like the previous four releases, it is a satirical simulation of the end of the world, fought out with nuclear weapons. It offers up new cards, expanded player mats, and a new propaganda system. The new game also offers the ability to play with up to six players and is backwards compatible with the other game. This game is for two to six players, ages 14 and up, and plays in 30-60 minutes.

The Kickstarter currently stands fully funded and has a retail tier available. For a $75 pledge, the Retailergerm tier offers stores a deposit on one case of the Nuclear Destruction game, plus Stretch Goals and early access.