Deadpool debuted in 1991, and this collection gathers 25 years of Wade Wilson wackiness. There are run-ins with Juggernaut, Black Panther, Daredevil, Black Swan, and Typhoid Mary. The tome includes contributions from Rob Liefeld, Fabian Nicieza, Joe Kelly, Christopher Priest, Gail Simone, Daniel Way, Cullen Bunn, Gerry Duggan and Brian Posehn. The cover is by Scott Elmer.

The 784-page book collects New Mutants (1983) #98; Deadpool: The Circle Chase #1-4; Deadpool (1997) #6-8, 44, 65-69; Daredevil/Deadpool Annual '97; Black Panther (1998) #23; Cable & Deadpool #20-23; Deadpool (2008) #16-18; Deadpool Kills The Marvel Universe #1-4; Deadpool (2012) #15-19; and Deadpool Secret Comic Variants.