Lairs & Lost Chambers introduces the enigmatic Sphinx, a Medusa, and Living Statues to Clank! Catacombs. It also adds lost chambers to the dungeon, which hold mysterious powers. The game box comes with 12 Dungeon tiles, 50 cards, 3 Living Statues, a Medusa, a Sphinx, and rules to incorporate this expansion into the base game.

The expansion and the base game (see "'CLANK! Catacombs'") supports two to four players, ages 13 and up, and plays in 45-90 minutes.