Marvel Comics has finally admitted what its series of teaser images had made plain, Peter Parker, the original Amazing Spider-Man will meet Miles Morales, the new Ultimate Spider-Man in the five-issue Spider-Men series written by Brian Michael Bendis and drawn by Sarah Pichelli that will debut in June.  This will mark the first ever "crossover" event between the mainstream Marvel universe (the 616 universe) and the Ultimate Marvel universe (aka "Earth-1610"), which the publisher debuted in 2000 to attract new readers beyond the normal Marvel fan base by creating stories featuring newer versions of the major Marvel characters, who were largely relieved of 4 decades of continuity to make them more accessible.
 
Although starting in March, Marvel began teasing the Peter Parker/Miles Millar crossover relentlessly in the comics industry press (see "When Marvel Universes Collide" & "Mainstream/Ultimate Crossover in 'Spider-Men'"), the House of Ideas broke the actual confirmation of the crossover in The New York Daily News.  There is very little in the way of actual news in the story—the major reveal is that the crossover saga will use “a common villain to bring the two heroes from different alternate realities (together).”  Marvel is being typically tight-lipped about the events that bring the two Spider-Men together
 
While the mechanics of the crossover saga remain in doubt, it appears likely that Marvel has found a way with this new Spider-Men series both to appeal to long time readers, who will fully appreciate the rarity of this occasion, and potentially to new readers whose interest in Spider-Man comics may be piqued by Marc Webb’s reboot of the Spider-Man movie franchise.