In Wise Guys, players take charge of rival gangs who are vying to become the most infamous bootleggers in Chicago during the Prohibition era. Players will double-cross rival gangs, help politicians get elected, and fight for control of locations throughout the city where they can buy and sell alcohol. They will also assume control of real-life gangsters like Al Capone, Dean O'Banion, and Ralph Sheldon, and issue orders to their Made Men to manage their turf. The gang that accumulates the most money by the end of the game wins.

The game box comes with a rulebook, 4 Clubhouse cards, 4 Asset Blinds, 24 Location tiles, a Roaring 20s tile, 40 Gang Member tokens, 33 Order tokens, 189 Asset tokens, 4 Clout tokens, a Black Market card, and 4 dice.

Galeforce Nine also recently announced CHOAM & Richese, a house expansion for Dune: A Game of Conquest, Diplomacy & Betrayal board game (see "'Dune: A Game of Conquest, Diplomacy & Betrayal' House Expansion").