Mezieres is best known to English-speaking readers as the artist of the science fiction fantasy Valerian and Laureline. He and Christin initially planned to do a Western, but Pilote, the comics magazine that ran their work, had plenty of those, so they switched genres. Their tale of two 28th-century special agents who travel through time and space at the behest of the Terran Galactic Empire ran from 1967 to 2019, and it appears to have influenced some of the visuals in the Star Wars films; when Mezieres saw the first movie, he remarked that it was like looking at a large-screen adaptation of his books.
While the rest of Mezieres’ work is not available in English, he had a lengthy career and received a number of lifetime achievement awards, including the Angouleme Grand Prix in 1984, an Inkpot Award in 2006, and the Max & Moritz Prize in 2018. His final work was L’Art de Mezieres, a collection of his sketches and commercial work, which was released by the French publisher Dargaud in 2021.